The Texans (3-1) have officially ruled out Mixon, along with defensive ends Derek Barnett (shoulder) and Jerry Hughes (hip) ahead of the matchup with the Bills (3-1).
At 28 years old, Mixon remains Houston’s top rusher, accumulating 184 yards on 39 carries over two starts. He injured his ankle during the Week 2 victory against the Chicago Bears. Hughes, 36, has recorded one tackle in four games, while Barnett, 28, has contributed seven tackles, two sacks, and one forced fumble in the same number of games.
Wide receiver Tank Dell, who sat out last week’s win over the Jacksonville Jaguars due to a chest injury, was limited in practice on Wednesday and Thursday but participated fully on Friday and has no injury designation.
Dell, 24, is third on the team with 99 yards from nine receptions and sustained bruised ribs in the Week 3 loss to the Minnesota Vikings.
Running back Dameon Pierce (hamstring) was limited in Friday’s practice after missing the previous sessions and is listed as questionable. The 24-year-old has only appeared in one game this season, a win against Indianapolis on September 8, where he recorded three carries for 16 yards.
Also questionable for Sunday’s game are linebacker Jake Hansen (back), defensive tackle Kurt Hinish (calf), defensive end Dylan Horton (illness), offensive tackle Tytus Howard (hamstring), and wide receiver Robert Woods (foot).
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